sudosussudio decided to see what happens if you mistreat Baldur's Gate 3 characters. This was done for scientific purposes, as he investigated the level of disapproval for choices.
To do this, he had to examine the script of Baldur's Gate 3 version 1.0. It turned out that Karlach is the record holder: if a player sleeps with her for the first time and then dares to say it was a mistake, they receive a -100 point penalty. For comparison, if the Dark Urge kills a companion, that is -10 points.
In second place are Jaheira and Minsc: if you tell Sarevok that you offer to sacrifice Minsc / Jaheira / both, that is -50 points with the respective character.
Third place is shared by Gale and Karlach. If, playing as Astarion, you persistently convince Gale that the character is not a vampire (even when it is already obvious), that is -30 points. If you break up with Karlach and say that you enjoyed it, but it is time to stop, that is -30 points.