If you're a fan, you won't get lost. The game takes place between the events of TD1 and TD2, so it's canon. But if you're not a fan, if you're playing for the first time, you're welcome too. You don't have to be a fan to have fun.
He added that the first seconds of the game include a training course: you will be taught how to shoot, squat, use cover and control the battle. Fans will be able to meet familiar elements of the universe, but this is not necessary to enjoy the game.
The Division Resurgence is a project option for fans before the release of TD3, as well as an entry point for newcomers looking for a mobile looter-shooter.