Recently, the developer of Vampire The Masquerade Bloodlines 2 spoke about the playthrough time for different playstyles.
Design Director Jay Hicks cannot give exact figures, but there is an approximate estimate:
"...at the moment, our estimate [of playthrough time] for those who play quickly and do not master additional content is, perhaps, 20–25 hours, and for those who prefer to complete the game fully, it is about 40 hours."
For comparison, according to HowLongToBeat, players spent from 23 hours (main story) to 39 hours (\"full\" playthrough) to complete the first Bloodlines.
Vampire The Masquerade Bloodlines 2 is expected to be released on October 21, 2025.