The project is described as a "cat roguelike" with tactical battles and deliberately strange situations. The game retains McMillen's characteristic humor and emphasis on non-standard gameplay.
The developer admitted that Mewgenics was not easy: the project was created for six years, and the work turned out to be exhausting for the entire team. At the same time, McMillen deliberately abandoned the simplest solution — the announcement of The Binding of Isaac 2. According to him, he wanted to do something new, and not a sequel, which would almost certainly become a commercial success.
The Mewgenics developers noted:
We could have just made The Binding of Isaac 2 and this "very simple" sequel to one of the best roguelike games of all time would literally have 20 million additions to the wishlist at the moment of the announcement.